Comparison between intranasal dexmedetomidine and intranasal midazolam as premedication for brain magnetic resonance imaging in pediatric patients: A. Intranasal dexmedetomidine has been used an effective and safe alternative premedication to oral midazolam in children. At a dose of 2micrograms/kg. Background Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable.

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To our knowledge, sleep time and the use of DEX in any formulation has not been previously observed. Cardiovascular effects of dexmedetomidine sedation in children. Thank you for sharing your experience. To dexmedetomidibe bias, observers and attending anesthesiologists were blinded to the study drug. Comparison of two different intranasal doses of dexmedetomidine in children for magnetic resonance imaging sedation.

In this study, we hypothesized that IN DEX is effective in providing adequate sedation for non-invasive procedures. Intranasal dexmedetomidine for sedation in children undergoing transthoracic echocardiography study: Dexmedetomidine, midazolam, intranasal, magnetic resonance imaging.

Our dosing is very similar: In this study, the time of onset of sedation is 8. This allows for administration of a small volume which is dispensed quickly.

Preanesthetic sedation of preschool children using intranasal midazolam. Abstract Background and Aims: On the day of the non-invasive procedure, the physician providing the sedation evaluated each subject. It acts on the locus coeruleus and produces an unusually cooperative form of sedation, in which the patient is calmly and easily aroused from sleep to wakefulness and subsequently quickly falls back asleep when not stimulated, which is similar to natural sleep.


Results The demographic profile was comparable between the two groups [ Table 1 ]. The demographic profile was comparable between the two groups [ Table 1 ]. Subjects 6 months to 18 years of age undergoing non-invasive elective procedures were included. However, the non-DEX cohort had a longer preprocedure time Table 5.

High dose dexmedetomidine as the sole sedative for pediatric mri. Leave a Reply Cancel reply Your email address will not be published. The total number of subjects undergoing sedation without DEX for similar procedures was males and females. Sedation was considered successful when the patients were calm and sedated, were not crying and agitated, and allowed smooth induction.

We did not nitranasal side effects between the IN DEX cohort and each of the sedation medications individually xexmedetomidine to inadequate sample size, but we believe that this should be addressed in future studies. Table 2 Comparison dexmedetomicine successful parental separation between the groups. Please review our privacy policy. It gives us as providers another option besides chloral hydrate or placing an IV for medications and seems to be a little more predictable.

Intranasal Dexmedetomidine as a Sedative for Pediatric Procedural Sedation

Footnotes Disclosure The authors declare no conflicts or financial interest in any product or service mentioned in the manuscript, including grants, equipment, medications, inranasal, gifts, and honoraria. University of Michigan Sedation Scale. Sedation challenges in the pediatric ICU: Further Study All of this is anecdotal and should be studied further. This pharmacokinetic profile can facilitate brief periods of deep sedation often needed for imaging procedures in pediatric sedation.

Comparison of the nasal and sublingual routes. Due to this demand, the role of pediatric critical care providers, hospitalists, and emergency physicians has also expanded to include PSA. Support Center Support Center. He was recovered in the PACU for an hour and was discharged. There has been increasing interest in the clinical application of dexmedetomidine in the intrwnasal population. Further research using IN DEX would benefit from a large multicenter, which could include investigation of inteanasal effect of procedure type on success.


In addition, the use of the nasal MAD mucosal atomization device has allowed quick and even administration of the drug.

Intranasal Dexmedetomidine | Pediatric Sedation Blog

Introduction The importance of procedural sedation and analgesia PSA for dexmeedtomidine undergoing procedures and imaging studies has led to an increase in demand for sedation outside of the operating room. The patients were randomly allocated to two groups. Investigations conducted by Yuen et al.

Correspondence Natalie Behrle, MD, ude. Since this drug has a neutral pH it is virtually painless when given intranasally. Premedication with midazolam in children.

It appears from my clinical view that the family members appreciate having another option and feel they have more control as we dexmedetomudine them to hold and rock their child to sleep with this technique.

The baseline HR was comparable between the groups [ Figure 1 ]. It has been very beneficial for our practice. This article has been cited by other articles in PMC.